• Does CMT cause elevated CK (Creatine Kinase) serum levels?

    >CK levels are often elevated in CMT patients, usually in about the 300 range. This is probably the result of denervated muscle. CK levels should NOT be > 1,000

  • Can CMT cause erectile dysfunction?

    There is remarkably very little on this subject. There has been some discussion of sexual issues in women, and erectile dysfunction in men was reported in 1994 by Dr. Tom Bird. There is also a reference to an article by Berghoff in 2009.

    We know that many neuropathies are associated with sexual dysfunction- diabetes is well described. So CMT could directly impact sexual function. But we just do not have enough research on the subject to give you solid data.

  • Can CMT cause aphasia?

    No. Aphasia is a language problem due to a brain lesion such as stroke or tumor. It has no relationship to CMT.

  • Is there any relationship between CMT and PAD (peripheral artery disease)?

    We are not aware of any relationship between CMT and PAD or arterial disease. Patients with very weak feet and legs can have cold feet that turn purple, but this is not arterial.

  • Does CMT affect blood pressure?

    As far as we know, CMT does not directly affect blood pressure.

  • Can CMT affect the heart?

    As far as we know, CMT does not affect the heart. CMT also does not affect the autonomic nervous system (ANS). The ANS is a part of the peripheral nervous system that regulates the functions of our internal organs, such as the heart, stomach and intestines.

  • Does CMT affect heartburn?

    >As far as we know, CMT does not directly cause heartburn.

  • I have developed flat feet and muscle wasting above the knees and into the thighs. Is this CMT or something else?

    Though these symptoms are not the most common symptoms of CMT, they are still in the realm of what is possible with CMT disease. People with CMT can present with flat feet and have muscle wasting above the knees and into the thighs.

  • Does CMT cause migraines?

    No. As far as we know, migraines are not a symptom of CMT.

  • Is there a link between hearing loss and areflexia?

    No, there is not a direct link between hearing loss and areflexia. It is true that people with many types of CMT, particularly types of CMT that affect myelin, have complete absence of deep tendon reflexes. A number of these cases may also have hearing loss secondary to their CMT.

  • Does CMT cause difficulty losing weight?

    As far as we know, there is no direct link between CMT and inability to lose weight. However, lack of exercise and fatigue can cause people with CMT to be sedentary. Some medications may cause weight gain, and thyroid issues or other medical conditions may make losing weight difficult. We suggest you see your doctor and a good nutritionist to help you with your weight loss.

  • Are myoclonic spasms a symptom of CMT?

    As far as we know, myoclonic spasms are not associated with CMT. However, muscle cramps are very common with CMT.

  • Is there a relationship between mitral valve prolapse and CMT?

    We are not aware of any relationship between CMT and mitral valve prolapse or, in fact, between CMT and any cardiac disease.

  • Can CMT cause shingles?

    CMT does not cause shingles, but shingles can cause an increase in nerve pain and worsening peripheral neuropathy.

  • Can CMT cause major depressive disorder?

    CMT does not cause major depressive disorder. However, people with CMT are more vulnerable to depression because they have to cope with a progressive illness.

  • Is there a connection between CMT and epilepsy?

    CMT is a disorder of the peripheral nervous system; epilepsy is a problem of the central nervous system. They are not likely to be connected.

  • Can CMT cause tremors?

    Tremors can be related to CMT. Clinically, when someone has CMT and a tremor, they sometimes call this Roussy-levy syndrome. Tremors are thought to occur because of decreased sensory input to the brain about where fingers are in space (pseudoathetosis) so that fingers (and sometimes legs or trunks) have tremors. Please consult your neurologist to understand if your tremors are CMT-related.

  • Do high zinc levels cause or worsen CMT? My father wears dentures, and denture-adhesive agents such as Fixodent and Polygrip contain zinc. I’ve read that high levels of zinc have been found to cause peripheral neuropathy, balance issues, weakness, numbness, etc.

    We know of no special link between zinc and CMT, but it is true that excessive zinc causes the body to lose copper. Copper deficiency is a cause of sensory loss, imbalance, neuropathy and leg stiffness. All of these problems will interfere with function in CMT patients and potentially worsen the degree of neuropathy. However, a significant amount of extra zinc is needed to produce the problem. Eating coins, especially pennies, is one way to ingest excessive doses, but few people have that urge. Excessive supplements are also an issue but large doses are needed. People with the dental adhesive exposure used quite a bit more than manufacturer recommendations. One simple question is how long a tube of adhesive lasts. Many affected patients used one or more tubes a week to secure poorly fitting dentures; one tube should last at least 4-6 weeks. However, zinc has been removed from the latest formulations. If there is any doubt, copper and zinc levels are easily tested in the blood.

  • Is there a relationship between idiopathic/vasomotor non-allergic rhinitis and CMT?

    As far as we know, there is no association between CMT and idiopathic/vasomotor non-allergic rhinitis. However, if the patient and doctor think this could be cause by the nerves, they might want to try treating with nerve pain meds such as gabapentin.

  • Have you ever heard of having elevated alkaline phosphonate levels due to CMT? My ALP has been climbing the last 6 months and my doctor is convinced it’s CMT-related.

    As far as we know, there is no relationship between alkaline phosphate levels and CMT.