Which acid reflux medications should I avoid?
Prilosec and Prevacid are in a class of medications termed proton pump inhibitors that include some of the following:
- Omeprazole (brand names: Losec, Prilosec, Zegerid, Ocid, Lomac, Omepral, Omez)
- Lansoprazole (brand names: Prevacid, Zoton, Inhibitol, Levant, Lupizole)
- Dexlansoprazole (brand name: Kapidex)
- Esomeprazole (brand names: Nexium, Esotrex)
- Pantoprazole (brand names: Protonix, Somac, Pantoloc, Pantozol, Zurcal, Pan)
- Rabeprazole (brand names: Rabecid, AcipHex, Pariet, Rabeloc)
One of the side effects that the Prilosec label says should be reported to a physician is numbness and tingling of the hands and feet. Since I already have numbness and tingling of the hands and feet, I’m not sure if I should continue taking it. Is Prilosec contraindicated for people with CMT?
I have been on Prevacid for years. I switched to Prilosec recently. I then found out it was on the Medical Alert list. I told my doctor and she switched me to Protonix, which is not on the list. However, she said it is in the same class of drugs as the two on the list. Why would that happen?
I recently had an endoscopy and was told to start taking AcipHex for my gastritis and duodinitis. Is this a safe medication for CMT? I see that Prilosec is on the drug list. Is AcipHex a similar compound?
Can alpha lipoic acid help those with CMT?
Will muscle relaxers affect my CMT?
Are any of the ingredients in the sleep aid Ambien harmful to people with CMT?
I have CMT. Will Lasik surgery pose a problem?
I took Nitrofurantoin (100mg 2Xday) for four days and then realized it was on the neurotoxic drug list. Should I be concerned about worsening CMT symptoms?
I work in a hospital and am required to get a hepatitis B immunization, but I’ve heard of a person whose CMT was supposedly triggered by that shot. Should I get it?
Is whooping cough vaccine contraindicated for children with CMT?
Are any vaccines contraindicated for CMT patients?
My 18-year-old daughter has CMT1A with relatively mild-to-average symptoms. She had a meningococcal vaccine and a flu vaccine, which are recommended for freshman college students staying in dorms. Nine days later, she started having extreme tingling sensations in her hands, feet and tongue as well as severely increased weakness. She fell six times while walking one block. I took her to the ER. They ran several tests and couldn’t find anything wrong in the blood work or in the urinalysis. Could the vaccine have caused these symptoms in a CMT1A patient? If so, how long should the symptoms last? They started five days ago and have improved slightly. She still has the tingling sensation in her feet and occasionally in her hand. She is now able to walk short distances with some assistance.
What about taking anti-depressant medications?
I'm taking medicine for depression. The label says I shouldn't stop taking it without my doctor's advice. What could happen?
Once you and your doctor decide to stop the medication, the dose should be gradually reduced over a few weeks to avoid the chance of withdrawal symptoms. Some experts recommend tapering the dose down over a period of one week for every month you’ve been on the drug–six to eight weeks if you’ve been on the drug for six to eight months, as a rule of thumb. During this time, you and your doctor should be watching for evidence of withdrawal symptoms or a depression recurrence.
Older antidepressants like tricyclic antidepressants and monoamine oxidase inhibitors have been known to cause discontinuation effects. The most common effects seen in the case of tricyclic antidepressants such as Tofranil and Elavil are upset stomach and nausea, flu-like symptoms, anxiety, low mood, and sleep disturbance. In the case of stopping monoamine oxidase inhibitors, such as Nardil, you may experience disorientation, confusion, mild movement disturbances, and even hallucinations.
It is also becoming increasingly evident that the newer class of antidepressants, called selective serotonin reuptake inhibitors, or SSRIs, such as Paxil and Zoloft, also have discontinuation effects. The most common are dizziness, lightheadedness, weakness, headache, stomach upsets, sleep disturbances, and anxiety. Problems have also been described with some even newer antidepressants, such as Effexor.
An endocrinologist who is treating me for diabetes has asked me to inquire if it would be appropriate to administer a statin-based cholesterol drug with my history of elevated CK's (generally 350-500 range)?
Are there any negative side effects to taking Gabitril for a mood disorder with my CMT?
I am a 35-year-old male who has been lifting weights off and on since I was 17. I have been hearing a lot about the use of creatinine to augment strength workouts. Is creatinine contraindicated with CMT?
I am interested in learning more about the CMT neurotoxic drug list. Why is a drug placed on the list? What is a mega dose? Regarding pyridoxine (Vitamin B6), should we avoid multivitamins with B6?
Why are certain drugs considered neurotoxic for CMT patients? Is there general knowledge of what happens when these items are ingested by someone with CMT?
Are there any antibiotics a person with CMT should not use? My doctor has prescribed Cipro for a urinary tract infection.
You should also be aware of alcohol and excessive doses of vitamin B6. Taking doses of 100 mg per day or more can potentially damage peripheral nerves. I generally recommend that people not take more than 25 mg of B6 per day unless there is medical reason for a higher dose.
There is a long list of drugs that have no more than a slight effect on peripheral nerves. I do not advise my patients to worry about these drugs when they are taken for a limited time. Your doctor can always look up a drug in the Physician’s Desk Reference to check for you.
Is it okay for someone who has CMT Type II to use Mycolog II Cream (Nystatin and Triamcinolone Acetonide cream) for dermatologic use?
Is there a cholesterol medication that people with CMT can take?
You have statins listed on your general drug list, and you have several specific statins listed on your expanded drug table, but rosuvastatin (Crestor) is not listed. Should it also be on the list?
My doctor would like me to discontinue Premarin and Fosamax. She asked if this is contraindicated. I am 65 and have had CMT since childhood. Bone density is the reason I've been on Premarin for 12 years.
Would you please comment on the possible neurotoxic effect of Tylenol, aspirin, and Advil as over-the-counter pain relievers for CMT patients?
I have been having a problem with osteoporosis and my doctor feels that the problem might be related to my CMT. He wants to start me on estrogen and I am wondering if it will cause me any difficulties?
My eldest son had problems buttoning his shirts until he began taking 500 mg. of L-histidine per day, which helped his hand function. We've been told that this essential amino acid is important for the maintenance of the myelin sheath that protects the nerves. Because he is also diabetic, he does not consume much rice or bread which, I understand, are natural sources of L-histidine. Have there been any studies on the effect of this amino acid on CMT patients?
Do beta blockers like atenolol have adverse side-effects on CMT patients? I have already noticed that my extremities are much colder since I started on atenolol. Fatigue and muscle weakness are noted as possible side effects. What is your opinion on the use of beta blockers by people with CMT?
Over the years, I have tried a variety of medications to treat my CMT pain. Recently, I was advised to take Neurontin (gabapentin). A whole new pain-free life has been opened up for me. I've tried to find information about how Neurontin works to stop the pain, give me stamina and better balance. Have there been any studies on the benefits of Neurontin for people with CMT?
I am going to have an endoscopy and the doctor is planning to use Versed. Is there a danger from this drug? I had the procedure previously and chose not to use this medication.
Are people with CMT prone to reactions from anesthesia when having surgery?
I am scheduled to undergo a colonoscopy, and I am told that a type of nuclear medicine will be used during the procedure. Are nuclear medicines dangerous for someone with CMT?
My doctor has informed me that he will administer propofol during my colonoscopy. Do I have any cause for concern?
I am taking biotin because I have brittle nails, but I am concerned because it is listed as B-complex. Can biotin have an adverse effect on CMT?
I’ve been on Coumadin for 15 years and I’ve recently noticed changes in my PT/PTT (tests for blood coagulation). I have also been taking Neurontin and Pamelor to reduce the symptoms of neuropathy for the last eight months. Are there any possible side effects from the use of these drugs?
I am 54 years old with shortness of breath not related to heart, emphysema, bronchitis or any other obvious reasons. For a period of two years, I was taking Macrodantin daily, and increased the dose when urinary tract infections (UTI) would flare up, so all in all, I’ve taken quite a bit. Last year, (while still on the drug), I developed severe shortness of breath that prohibited me from walking. My rheumatologist figured out that the Macrodantin might be the culprit. So, the drug was stopped and the breathing did improve. Yet, after being off the drug for a year, my shortness of breath continues, although certainly not as severe as it was while taking the drug. I have an upcoming appointment with a pulmonologist, and was hoping to be armed with a little more information prior to the appointment. Can you tell me if this drug adversely affects CMT patients?
About 6 years ago I had prostate surgery and was previously on Androderm patches. In prep for surgery I had to stop the Androderm and since then I have noticed a marked weakness in my legs. I have asked my doctor to prescribe Androderm again for a while to see if it will help in any way. Is the use of Androderm advised or not?
I have been taking 15mg/day of prednisone for five days for osteoarthritis, and I have experienced a sudden onset of muscle weakness in my lower legs. I was told to reduce my intake to 5mg/day, which I did yesterday, but I have not yet noticed any improvement. Is there any reason for me to be concerned about taking prednisone?
I have CMT and recently have been undergoing treatments for breast cancer. After finishing four treatments of Adriamycin, my legs became so weak that I was unable to walk. A nerve conduction study showed no detectible nerves in my lower legs. The neurologist thinks that the Adriamycin made the neuropathy that I already had worse. The oncologist said he had never seen any documented case of this happening. I would appreciate any explanation that you could give me.
A close member of my family who has CMT took Lamisil pills for three weeks for the treatment of a fungus infection on his toes. After three weeks, he got a strange rash and was unable to move his arms and legs. He immediately stopped taking the pills, and after a week, he is still paralyzed. My questions are: 1) Do you know of any similar cases with CMT patients and this drug? 2) Will his paralysis be reversible? 3) Can we assume that this drug worsened his CMT condition?
I am bi-polar and take 1800mg of Eskalith (lithium carbonate) a day. I was diagnosed with CMT in 1999 and since then I have developed a problem with severe shaking, as if I were really cold. I would appreciate any information you can give me about this.
I have been taking Reglan for intestinal problems while in the hospital. I believe it has caused a serious balance problem for me, and I wonder if it should be on the CMT drug list. I also take heavy doses of Lomotil (diphenoxylate/atropine) for ulcerative colitis.
We have looked on the list and read that oral antibiotics are okay for CMT patients; however, we were wondering about the 30-day antibiotics. Are they too strong for people with CMT?
I have extreme hot flashes/sweats day and night affecting my duty in the military and my personal life. Since I also have CMT1A, it’s much worse to deal with. I’m about ready to go back on HRT (hormone replacement therapy) but an endocrinologist saw a study that suggested progesterone might be bad for me. The endocrinologist is suggesting Serafem instead.
Serafem is a completely different type of agent and is the same chemical as Prozac (fluoxetine). I do not know the literature well, but do not think the success with these types of agents has been terrific in treating perimenopausal symptoms, though the risk of trying is low. The only agent in that group that has been questioned about a detrimental effect on CMT is Paxil (paroxetine).
Your medical alert lists the risk of pyrixidine as Moderate to Significant. I now have a prescription for Metanx, which includes 25 mg of pyridoxal 5’-phosphate (B6). Is that the same or a problem?
My doctor prescribed a 90-day dosage of the vitamin B supplement Metanx for elevated cholesterol. I stopped taking it about two weeks ago, and soon after that my body started breaking out in rashes everywhere except my face. It itches and leaves ugly marks like chicken pox, which I had as a kid, more than 50 years ago. I cannot figure out what else might have happened, except for a minor gum surgery soon after, where novocaine (I believe) was used for anesthetic purposes. The only other medication I take is Accupril for blood pressure. Do you know if Metanx has any withdrawal effects?
Has there been any investigation regarding the use of methylcobalamin in treating people with CMT?
I have had CMT for more than 20 years. I also have diabetes and have been on kidney dialysis. I am going to have a kidney transplant soon and would like to know if the drugs are going to affect my CMT?
I am a 53-year-old female who was diagnosed with CMT about 13 years ago. I was recently given a prescription for Amerge 2.5 by my neurologist and it made me feel like I couldn't move my legs. I also had severe cramps in my lower extremities. Are those side effects related to the medication?
I know that statins are listed on the drug watch list for their possible effect on muscles. However, recently I have been reading that Zetia may also affect people with CMT. I have CMT Type 1A and have been taking Zetia prescribed by my doctor to lower my cholesterol. It has worked as expected, but how do I know if Zetia is having a negative effect on my muscles? I have always experienced general muscle discomfort and pains, especially a lifetime of back problems and compound scoliosis. How can I discern if the Zetia is contributing to my pre-existing problems?
Zetia can cause toxicity to the liver, especially in patients that already have liver problems, such as chronic hepatitis C. An internist or gastroenterologist would be better to consult about these hepatic (liver) issues. I do not know the relative risk in this setting that appears to be separate from CMT.
Is there any information on the osteoporosis drug Evista (Raloxifene HCI) and its side effects on persons with CMT?
I am treating a 20-year-old patient with leukemia. After his fourth dose of vincristine, he had progressive, severe neuropathy in all extremities, dysphagia and dysarthria. EMG studies are consistent with CMT. Genetic studies are pending. We discovered after his treatment that his brother had an EMG 13 years ago that was consistent with CMT. The patient is in remission after induction chemotherapy. However, he needs additional chemotherapy. Can you give me any additional information as to why Adriamycin is in the uncertain category? Have any patients received high-dose cytarabine?
My husband has CMT and hepatitis C. He has been on Pegasys and Copegasys for 10 weeks now. I think that the effects he feels are more severe than what other people experience. Are there any studies on treating patients with both conditions?
Is there any reason why a CMT patient should not take Humira for rheumatoid arthritis?
My son is 20 and has just been diagnosed with CMT1X. He also has tremors of the hands. The doctor has prescribed Inderal LA 80 for the tremors. Will this work or have any effect on the CMT? Do you have any other suggestions about this?
Do Lupron Depot 3.75 mg injections (1x/month) cause any know problems with CMT patients? I know it can cause 3 percent bone loss, which is one reason it is only administered for six months at time. I have been noticing wasting in my shoulders, hips, arms, under my ribs (front and back), and right calf. My father, two sisters (one deceased), male cousin and I all have CMT. I also have antiphospholipid syndrome, which means my anticardiolipin antibody igm and beta2 glyprotein igm are elevated, causing my blood to clot. I just recently had a heart attack due to a blood clot.
A lot has been written recently about lawsuits against suggesting that Lipitor causes peripheral neuropathy. Do you think this is a problem that CMT patients should consider?
I was just diagnosed with macular degeneration. The specialist told me there is a new treatment in which the cancer drug Avastin is injected into the eye. I read in The CMTA Report that some cancer drugs are harmful to CMT patients. Is this one of them?
I’m having surgery and will be given Versed. I read somewhere about being careful with Versed. I have CMT 1A and am wondering if that medication will be okay.
I have been taking the anti-fungal drug Nystatin for years to control Meniere’s disease. Is Nystatin a member of the statin family or is it just an accident of name?
Is there any reason why a patient with CMT should not take antimuscarinics such as Vesicare to treat overactive bladder?
My 9-year-old son was recently diagnosed with CMT Type 2, x-linked, with central nervous system demyelination. So, in addition to the regular CMT findings, he also was found to have white matter lesions on his brain MRI. Prior to the CMT diagnosis, my son was being treated for ADD. We had taken our son off Focalin XR, 20 mg. in mid-June for a summer rest. The initial CMT episode happened three weeks later. Is this type of medication contraindicated with CMT?
I recently read about Zostavax, a vaccine against shingles. Patients 60 years of age and older are advised to have this. Is there any evidence that a person with CMT should not take this?
Is Effexor safe for a person diagnosed with CMT?
Is the combination of verapamil and Avapro as blood pressure medications considered neurotoxic? I take the above medications and my symptoms appear to be worse.
My mother and I both have CMT. She passed away last June and was disabled for several years before that. My condition has been worsening rapidly. After her death, I poured over some of her books (she was a psychiatrist) and found that benzodiazapines are very effective in treating pain. I am currently taking Klonopin and Cymbalta. I haven’t seen anything in recent literature about benzodiazapines. Has research changed those earlier findings? Cymbalta has almost completely eliminated my shooting pains. Is there a generic form?
I am a 25-year-old who was diagnosed with CMT by EMG. My doctor also diagnosed me with Charcot joint, osteoarthritis, and lumbar disc syndrome. I have had numerous fractures and sprains throughout my lifetime, and a few years ago I had a deformed bone taken out of my right foot and screws put in to tighten my ligaments. My doctor has me on 20 mg of methadone for long-acting pain relief and Vicodin for breakthrough pain. I also take Valium for anxiety. The pain has decreased quite a bit, but since starting the methadone, I have been waking up with numbness in my hands and my hands in a clawed position. The doctor says that in order to stop this medication, I must be slowly weaned off of it. Could the medication be making my CMT progress, and how safe are narcotic treatments for long-term use? I have tried Neurontin with little or no relief.
A man is concerned that the drug his oncologist wants to put him on might be related to vincristine. It is vinblastine. Could you let me know if he should be concerned?
Are there nutritional supplements and/or herbal supplements that should be avoided by a person with CMT? Can increased doses of magnesium citrate cause neurotoxicity? My chiropractor has me taking MyoCalm P.M. as needed for muscle tension. It contains 150 mg of magnesium citrate and 75 mg of calcium lactate, as well as other herbs. I reviewed the toxic drug list and did not see any mention of supplements.
I noticed on your medical alert page that you put amitriptyline in the negligible to doubtful risk category. I definitely had a very bad reaction to it. To date it was the worst of any other meds I have taken for CMT nerve pain. I have CMT and have tried many medications to ease the neuropathic pain. I have had little success. Vicoden is the most manageable without any major side effects or thought-process disruption. Neurontin caused me to break out with very painful cysts on my face and did little to ease the nerve pain. I recently was prescribed amitriptyline. The very first dose of 5 mg caused some weakness in my legs and increased back pain. On the fourth day, when I increased the dose to 10 mg, I suffered such severe back and leg pain that my daughter took me to the emergency room. By the time I returned home (seven hours later), my pain had eased quite a bit, so I went ahead and took the amitriptyline as prescribed when I went to bed. Within an hour I was in horrific pain again, lasting about six hours. Needless to say, I will not be taking this drug again.
I have CMT and had breast cancer a few months ago. The oncologist wants me to take Arimidex (anastrozole). I am rather concerned because of the side effects that can occur with any patient. Do you have any information about Arimidex and CMT patients?
Is Vitamin D helpful for people with CMT?
Has Botox been used in CMT to release hammer toes, Achilles tendons or anything else?
Do vitamins help with CMT?
I have CMT and would like to know if it’s okay to take vitamin B12 and B complex vitamins?
Are Lidocaine injections with epinephrine safe for CMT patients?
I am having some facial work done. Is hyaluronic acid okay?
What anesthetics should be avoided?
Alcohol used to be on the neurotoxic medication list. Will drinking alcohol make my CMT worse?
The CMTA website lists Metronidazole (Flagyl) as a neurotoxin with 'moderate to significant risk (extended use)' for individuals with CMT. What length of time constitutes 'extended use'?
Is Botox a safe and efficient treatment for people with CMT?
Will cosmetic botex injections (face) worsen my CMT?
If Quinine is a neurotoxic substance for people with CMT and Quinine is in tonic water, why is drinking tonic water recommended to people with CMT for nocturnal cramps?
The FDA has banned the use of quinine for nocturnal leg cramps because of its serious side effects. For most people, the low doses of quinine contained in tonic water are not enough to trigger serious side effects. So, most people can use tonic water occasionally and in moderation as a remedy for leg nocturnal cramps.
However, for an unlucky few, even the small amount of quinine in tonic water can cause thrombocytopenia. Thrombocytopenia is a drop in the blood’s platelet count that can lead to internal and external bleeding as well as a related condition that can cause permanent kidney damage.