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Research News

Identification of Drug Modulators Targeting Gene-Dosage Disease, CMT1A

[The abstract of a new paper by Sung-Wook Jang, Camilla Lopez-Anidos, Ryan MacArthur, John Svaren and Jim Inglese is presented below. Sung-Wook is a post-doctoral fellow funded by the CMTA.]

The structural integrity of myelin formed by Schwann cells in the peripheral nervous system(PNS) is required for proper nerve conduction and is dependent on adequate expression of myelin genes including peripheral myelin protein 22(PMP22), Consequently, excess PMP22 resulting from its genetic duplication and overexpression has been directly associated with the peripheral neuropathy called Charcot-Marie-Tooth disease type 1A(CMT1A), the most prevalent type of CMT. Here, in...

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CMT Subtypes and Genetic Testing

Please click on the attachment below to read the recently published article by CMTA Medical Advisory Board Chairman Dr. Michael Shy, and colleagues, on CMT Subtypes and Genetic Testing. The article was published in the Annals of Neurology.


 

Special CMT Edition of Journal of NeuroMolecular Medicine

A special 2-volume edition of NeuroMolecular Medicine is devoted exclusively to Charcot-Marie-Tooth (CMT) disorders. These volumes contain 18 articles on CMT written by the world's leading researchers and scientists.

The journal is a comprehensive reference tool...

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